![]() ![]() Significant associations emerged between PET features, CT features, and histological type in NSCLC. By contrast, adenocarcinomas exhibited significantly lower uptake, lower variability and higher uniformity than the other subtypes. Squamous cell carcinomas had larger volume higher uptake, stronger PET variability and lower uniformity than the other subtypes. Inter (PET-CT) correlation analysis identified a very strong positive correlation between the volume of the lesion at CT (CT vol) and the metabolic volume (MTV), a moderate positive correlation between average tissue density (CT mean) and radiotracer uptake (SUV max, SUV mean), and between kurtosis at CT (CT krt) and metabolic tumor volume (MTV). There was a positive moderate correlation between the metabolic tumor volume (MTV) and radiotracer uptake (SUV max, SUV mean). Conversely, there was a strong negative correlation between the uptake (SUV max, SUV mean) and its degree of uniformity (SUV uni). Intra-PET analysis identified a strong positive correlation between the radiotracer uptake (SUV max, SUV mean) and its degree of variability/disorder throughout the lesion (SUV std, SUV ent). ![]() ![]() A moderate positive correlation was found between volume (CT vol) and average density (CT mean), and between kurtosis (CT krt) and average density (CT mean). Intra-CT correlation analysis revealed a strong positive correlation between volume of the lesion (CT vol) and maximum density (CT max), and between kurtosis (CT krt) and maximum density (CT max). Feature extraction and statistical analysis were carried out on the Matlab platform (MathWorks, Natick, USA). We retrospectively evaluated the baseline PET/CT scans of 81 patients with histologically proven non-small-cell lung cancer. The study aims to investigate the correlations between positron emission tomography (PET) texture features, X-ray computed tomography (CT) texture features, and histological subtypes in non-small-cell lung cancer evaluated with 2-deoxy-2-fluoro-D-glucose PET/CT. ![]()
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